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ژن هترولوگ
A number of promoters derived from S. cerevisiae genes are available for engineering efficient transcription of heterologous genes in yeast vectors (Table 3.11).
Many heterologous genes are provided with a DNA coding sequence for a signal peptide that facilitates the passage of the recombinant protein through cell membranes and its release to the external environment.
Other sequences that stabilize the recombinant pro tein, protect it from proteolytic degradation, and provide a purification tag can be fused onto the coding sequence of the heterologous gene.
To remedy this problem, a heterologous gene is integrated into the host genome to provide a more reliable production system.
Briefly, a functional selectable marker gene and a heterologous gene equipped with yeastspecific transcription and translation control sequences are inserted between two DNA segments derived from the ends of a nonessential yeast gene.
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